On November 9, 2021, Detroit City FC announced its departure from NISA to join USL Championship.
2022 USL Championship
March 12, 2022: at San Antonio FC
March 19, 2022: Charleston Battery
March 26, 2022: Pittsburgh Riverhounds
April 2, 2022: Memphis 901 FC
April 5, 2022: Michigan Stars (US Open Cup)
April 9, 2022: at Atlanta United II
April 15, 2022: Birmingham Legion FC
April 19, 2022: Columbus Crew SC (US Open Cup)
April 30, 2022: New York Red Bulls II
May 10, 2022: Louisville City FC (US Open Cup)
May 14, 2022: Loudoun United FC
2022 USL W League
May 7, 2022: Kalamazoo FC
May 12, 2022: Racing Louisville FC