On November 9, 2021, Detroit City FC announced its departure from NISA to join USL Championship.

2022 USL Championship

March 12, 2022:  at San Antonio FC
March 19, 2022:  Charleston Battery
March 26, 2022:  Pittsburgh Riverhounds
April 2, 2022:  Memphis 901 FC
April 5, 2022:  Michigan Stars (US Open Cup)
April 9, 2022:  at Atlanta United II
April 15, 2022:  Birmingham Legion FC
April 19, 2022:  Columbus Crew SC (US Open Cup)
April 30, 2022:  New York Red Bulls II
May 10, 2022:  Louisville City FC (US Open Cup)
May 14, 2022:  Loudoun United FC

2022 USL W League

May 7, 2022:  Kalamazoo FC
May 12, 2022:  Racing Louisville FC